ACSL4 - Wikipedia
Long-chain-fatty-acid—CoA ligase 4 is an enzyme that in humans is encoded by the ACSL4 gene. [5] [6] [7] The protein encoded by this gene is an isozyme of the long-chain fatty-acid …
ACSL4 Gene - GeneCards | ACSL4 Protein | ACSL4 Antibody
Mar 30, 2025 · ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is a Protein Coding gene. Diseases associated with ACSL4 include Intellectual Developmental Disorder, X-Linked …
Acyl-CoA synthase ACSL4: an essential target in ferroptosis and …
ACSL4 remodels the phospholipid composition of cell membranes, regulates steroidogenesis, and balances eicosanoid biosynthesis. In addition, ACSL4-mediated metabolic reprogramming and …
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid ...
Nov 14, 2016 · We applied two independent approaches—a genome-wide CRISPR-based genetic screen and microarray analysis of ferroptosis-resistant cell lines—to uncover acyl-CoA …
Identification of a targeted ACSL4 inhibitor to treat ferroptosis ...
Mar 29, 2024 · ACSL4 contributes to ferroptosis by promoting the esterification of polyunsaturated fatty acids (PUFAs) to acyl-CoA, especially adrenic acid (C22:4) and AA (C20:4) . Therefore, …
ACSL4 acyl-CoA synthetase long chain family member 4 [ (human)]
ACSL4 reprograms fatty acid metabolism in hepatocellular carcinoma via c-Myc/SREBP1 pathway. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor …
ACSL4 as a Potential Target and Biomarker for Anticancer: From
Jul 13, 2022 · Recently, acyl-CoA synthetase long-chain family 4 (ACSL4) is found be participated in the activation of long chain fatty acids metabolism, immune signaling transduction, and …
Long-chain fatty acyl CoA synthetase 4 expression in pancreatic …
May 10, 2025 · Background Long-chain fatty acyl CoA synthetase 4 (ACSL4) is crucial for lipid metabolism, primarily catalyzing the formation of 12–20 carbon chain fatty acids. ACSL4 is …
The ACSL4 Network Regulates Cell Death and Autophagy in …
ACSL4 is an enzyme involved in the intracellular conversion of long-chain fatty acids and coenzyme A into fatty-acid coenzymes. It plays a vital role in various biological processes, …
The ACSL4 Network Regulates Cell Death and Autophagy in …
Jun 15, 2023 · In this review, we introduce the structure, function, and regulation of ACSL4; discuss its role in apoptosis, ferroptosis, and autophagy; summarize its pathological function; …