In Xenopus cells, a guide RNA generated from scaRNA, but not from snoRNA, could induce an additional pseudouridylation of U2 snRNA at position 60; both guide RNAs were equally active on a U2 ...

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To challenge this assumption and to explore the 700 snoRNAs that have yet to be functionally characterized, He developed the chemical crosslinking-based technique snoKARR-seq, which enables ...

The paper, "SnoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification," was published in November 2024 in the journal Cell. A molecular glue for protein ...

Wilson Distinguished Service Professor of Chemistry and Professor of Biochemistry and Molecular Biology at the University of Chicago and co-senior author of the paper The paper, "SnoRNA ...

He is the co-senior author of the researchers’ published paper in Cell, titled “SnoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification.” ...

The paper, "SnoRNA-facilitated protein secretion revealed by transcriptome-wide snoRNA target identification," was published in November 2024 in the journal Cell. A molecular glue for protein ...

Using this approach, they uncovered thousands of previously unknown snoRNA targets in human cells and mouse brain tissues. Remarkably, many of these targets have functions beyond rRNA modification.

Here, we show that a set of neutrally evolving long non-coding RNAs (lncRNAs) whose introns encode small nucleolar RNAs (snoRNA Host Genes, SNHGs) are highly expressed in skin and dysregulated in ...

Therefore, developing efficient computational methods is crucial for identifying potential snoRNA-disease associations. In this paper, a method to identify snoRNA-disease associations based on graph ...