This study provides useful information on the impact of Lamin A/C knockdown on gene expression using RNA-Seq analysis. In addition, the impact of Lamin A/C knockdown on telomere dynamics is explored ...

HS2’s TBM ‘Mary Ann’ has broken through today, marking the end of her mission to excavate the first bore of what will soon become the longest railway tunnel in the West Midlands. The 125m long, 8.62m ...

The New York City Department of Environmental Protection (DEP) has announced it will begin a new procurement and contracting ...

CYAD-211 is the Company’s first allogeneic chimeric antigen receptor (CAR) T-cell candidate, engineered to co-express a B-cell maturation antigen (BCMA)-specific CAR and a microRNA-based single shRNA ...

This groundbreaking work illustrates the possibility of applying short hairpin RNA (shRNA) technology in an RNA interference application to improve memory and significantly lower neural excitability.

In a groundbreaking study, they successfully used a non-invasive intranasal delivery platform to administer short-hairpin RNA (shRNA) that targets the 5-HT2A receptor resulting in long-lasting ...

GlobalData is the parent company of Pharmaceutical Technology. Vigil is a bifunctional short hairpin RNA (bi-shRNA) immunotherapy that modifies tumour cells to reduce furin enzyme levels, thereby ...

In this study, we develop miR‐AB, a new microRNA‐based shRNA (shRNAmir) backbone for simplified, cost‐effective, and error‐proof production of shRNAmirs. After verification of its potent RNAi ...

Here, we report a novel approach in which a microRNA (miRNA) or short-hairpin RNA (shRNA) cassette was integrated into CAR-expressing retroviral vectors. Using this system, we generated anti-CD19 ...

Lnc-THOR knockdown in stable cells was verified by qRT-PCR assays. Control cells were infected lentiviral particles with scramble control shRNA (“shC”). NSCLC cells were grown in a 10-cm culturing ...