Background and aims Quantifying systemic inflammation (SI) in acutely decompensated cirrhosis (ADC) is of major importance because SI is a driver of the most severe forms of ADC, including ...

Baby saved by gene-editing therapy 'graduates' from hospital, goes home. KJ Muldoon was diagnosed with a rare, deadly genetic disease after he was born. By Sony Salzman. June 4, 2025, 11:09 AM.

Gene therapies to treat rheumatoid arthritis have evolved slowly, but one is ready to move into human trials and an osteoarthritis treatment in human trials may have potential for treating RA.

Here they examined whether IL-11, a pro-inflammatory cytokine of the IL-6 family, has a negative effect on age-associated disease and lifespan. As mice age, IL-11 is upregulated across cell types and ...

Disruption of the IL-6 gene in cachectic C26 cells delays tumor growth, but still leads to body weight loss without elevated circulating IL-6. ( A ) IL-6 levels in conditioned media of cxC26 scr ...

SAN DIEGO — Janus kinase and interleukin-6 inhibitors are superior to other targeted agents as a first-line therapy for VEXAS syndrome, according to data presented at ACR Convergence 2023.&ldquo ...

After IL-6 activation, these tests were performed again at six weeks, three months and five months, and results were compared with mice that did not have the human IL-6 gene turned on.

Gene silencing studies in endothelial cells showed that ADAR2 controls IL-6 signalling in this cell type. The authors then used three mouse genetic models (IL6 loss, global ADAR2 loss, vascular ...

The authors found that expression of the IL-6 gene and gene signature along with Th17 cells are upregulated in tissues with colitis but not in biopsies from melanoma that has responded to ipilimumab.

Furthermore, the IL-6 gene signature was upregulated in those whose tumors did not respond to immunotherapy, but the increased levels were not seen in responders.

Furthermore, the IL-6 gene signature was upregulated in those whose tumors did not respond to immunotherapy, but the increased levels were not seen in responders.