We found an increase in the C3 cleavage products C3d and iC3b in HAE-C1INH patients, indicating increased C3 activation. These findings are in line with results from previous studies on HAE-C1INH ...

Retinal damage by NaIO 3 increased C3b fragment levels relative to iC3b, while KRIYA-825 treatment helped to suppress C3b to iC3b protein levels. In this dose range finding study in non-human primates ...

Modulation of C3b/iC3b and C3b/iC3b:C3 by PPY988 delivery. (A,B) C3b/iC3b concentrations (y-axis, ng/mL) in VH samples by week post-surgery (x-axis) from subjects in cohorts 1 to 4.

4626 Background: Pancreatic adenocarcinoma as an aggressive tumor still lacks specific markers. Resection offers the only potential cure, and earlier diagnosis could benefit many patients. Here, we ...

The complement system is recognised as a protector against blood-borne pathogens and a controller of immune system and tissue homoeostasis. However, dysregulated complement activity is associated with ...

Convalescent samples presented elevated concentrations of iC3b and TCC for up to 21 days following infection termination, suggesting COVID-19's role in complement activation, but these ...

Background A major unmet need in SLE is the identification of a biomarker that consistently tracks with disease activity. One current approach is measuring complement activation by evaluating ...

Background Complement activation is a hallmark of SLE pathophysiology. We previously found that iC3b/C3 ratios associated with active disease and clinically meaningful changes in SLE disease activity.

In red blood cells from patients with sickle cell disease, complement inactivated C3b (iC3b) and C5b-9 deposition resulted from exposure to heme and this was blocked by > 95% for iC3b and by > 85% for ...