Short-term inhibition of the mTORC1-4EBP1-eIF4F axis decreased the expression of proinflammatory cytokines such as Ccl2 (C-C motif chemokine ligand 2) of border zone cardiomyocytes, thereby ...

More information: Kyusik Q. Kim et al, eIF4F complex dynamics are important for the activation of the integrated stress response, Molecular Cell (2024). DOI: 10.1016/j.molcel.2024.04.016 ...

eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of the ...

eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of the ...

At the same time, we are also examining more closely the interaction of the mRNA specific initiation factors (eIF4A, eIF4B, eIF4F, eIF4H) with RNA. Both the characteristics of ideal RNAs for binding ...

eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of ...

Dr Anne Largeot, Senior Scientist within the TSI Group, First Author of the Study The study, titled "Inhibition of MYC Translation through Targeting of the Newly Identified PHB-eIF4F Complex as ...

eFFECTOR’s STRI product candidates target the eIF4F complex and its activating kinase, mitogen-activated protein kinase interacting kinase (MNK). The eIF4F complex is a central node where two of ...

The specific complex responsible for translating c-Myc is called the eukaryotic translation initiation factor 4F (eIF4F) complex. The eIF4F complex is translation machinery, which takes mRNA messages ...