The target, eukaryotic initiation factor 4E (eIF4E), is essential for the production of proteins linked to cell growth in a several tumour types – including breast and prostate cancer. Blocking this ...

The predominant signaling pathways leading to dysregulation of translational control in cancer are the PI3K-AKT-mTORC1, RAS-RAF-MAPK, and MYC pathways, which all converge on eukaryotic translation ...

Using advanced techniques like optogenetics, the study in Cell Reports reveals how mutations in the eIF4E gene impair neurotransmitter release, offering insights for diagnostics and new therapeutic ...

DURHAM, N.C., September 16, 2024--(BUSINESS WIRE)--Ribometrix, a biotechnology company developing small molecule therapeutics that modulate RNA biology, presented the latest data from its eIF4E ...

However, the synthesis of certain liver proteins increases during fasting, an effect that is mediated by phosphorylation of the eukaryotic translation initiation factor 4E (P-eIF4E). P-eIF4E plays ...

Share on Pinterest Scientists are looking at the effects of the keto diet on cancer therapies. Dulin/Getty Images A ketogenic diet can interact with certain cancer therapies to block the ...

Ruggero’s team first uncovered how a protein known as eukaryotic translation initiation factor (eIF4E) changes the body’s metabolism to switch to fat consumption during fasting. The same switch also ...

Ruggero's team first uncovered how a protein known as eukaryotic translation initiation factor (eIF4E) changes the body's metabolism to switch to fat consumption during fasting. The same switch ...

By tracking how different metabolic pathways changed during fasting, the scientists discovered that a protein called eIF4E was activated by the presence of free fatty acids, which are released by ...

It’s the end of an era—eFFECTOR Therapeutics’ era to be exact. The oncology biotech has laid off staff as it plans to wind down, according to a June 24 company release. This includes ...

Novel eIF4E inhibitors potently and selectively suppress tumor growth These preclinical data are the most advanced-to-date demonstration that inhibiting RNA-binding protein (RBP) eIF4E can serve as a ...