Ribosome attachment and scanning are impeded by structures in the 5′ UTR that can be resolved by RNA helicases Ded1 and eukaryotic translation initiation factor 4A (eIF4A), with cofactors eIF4B and ...

Another eIF4 factor, eIF4B, stimulates the RNA helicase activity of eIF4A and facilitates mRNA recruitment. However, the mechanisms by which eIF4B binds the 40S ribosomal subunit and promotes mRNA ...

Cerebral vascular malformations (CCMs) are primarily found within the brain, where they result in increased risk for stroke, seizures, and focal neurological deficits. The unique feature of the brain ...

At the same time, we are also examining more closely the interaction of the mRNA specific initiation factors (eIF4A, eIF4B, eIF4F, eIF4H) with RNA. Both the characteristics of ideal RNAs for binding ...

Find more information on the Altmetric Attention Score and how the score is calculated. Eukaryotic initiation factor 4B (eIF4B) is a multidomain protein with a range of activities that serves ...

Disruption of either the entire eIF3 complex or specific targeting of these subunits affects mRNAs with long 5′-untranslated regions and whose translation is more dependent on eIF4A, eIF4B, and Ded1 ...

Mounting evidence indicates that eIF4B is also important for translation initiation. It has been shown that eIF4B not only participates in the recruitment of ribosome in the process of eukaryotic ...

DEAD-box helicases mediate local RNA destabilization and unwinding in all processes involving RNA. Figure 1: The conformational cycle of the DEAD-box helicase core is linked to duplex destabilization ...

Partial yeast 48S PIC maps containing clear density for eIF5-NTD (py48S-eIF5N) were obtained from a 48S sample reconstituted by sequential addition of purified Saccharomyces cerevisiae eIF1, eIF1A, ...

In contrast to the core 43S PIC components and eIF3, leaving out eIF4B or eIF5 had no effect on the stimulation of the ATPase activity of eIF4A•4G•4E. Neither factor is required for formation of a ...