About IFB-088 (icerguastat) InFlectis is developing IFB-088 (also named sephin1), a first-in-class, multi-functional, brain-penetrant, orally administered small molecule that selectively inhibits the ...

More information: Ricardo A. Cordova et al, Coordination between the eIF2 kinase GCN2 and p53 signaling supports purine metabolism and the progression of prostate cancer, Science Signaling (2024).

Translational initiation at AUG codons is mediated by a ternary complex consisting of eIF2 (eukaryotic translation initiation factor 2), GTP, and initiator methionyl-tRNA. Global translation is ...

Eukaryotic translation initiation factor 2 (eIF2) is a G-protein that in its GTP-bound form binds to the initiator methionyl-tRNA (Met-tRNA i), yielding a ternary complex (TC), which is then recruited ...

Thaxton's lab found that when PERK is activated, modification of one molecule called p-eIF2 alpha is responsible for the T cell momentarily stopping protein synthesis during the stress response.

Here, we demonstrate that the eIF2 kinase GCN2 is required for sustained growth in androgen-sensitive and castration-resistant models of PCa both in vitro and in vivo, and is active in PCa patient ...

Conclusion: The molecular evidence using next-generation proteomics (NGP) revealed that retinal EIF2 signaling, glycolysis, and dopamine secretion through SNCA are implicated in atropine treatment of ...

Department of Biochemistry and Molecular Biology, Hengyang Medical School, University of South China, Hengyang 421001, Hunan, P. R. China The Key Laboratory of Ecological Environment and Critical ...

Abstract: Eukaryotic initiation factor 2 (eIF2) plays a fundamental role in the regulation of protein synthesis. Investigations have revealed that the regulation of eIF2 is robust against intrinsic ...

A study of molecular structure reveals how a small chemical change can make a big difference to function in a cell’s response to stress ...