This study provides detailed measurements of the movement parameters of the small subunit (SSU) during translation and illustrates the periodic binding of three elongation factors (eEF1A ...

Eukaryotic elongation factor 1 α (eEF1A) is vital for protein synthesis and an enigma in cancer research. While its overexpression is linked to aggressive forms of cancer, elevated levels of eEF1A ...

Structural factors in the human ribosome, and the human elongation factor, eEF1A help ensure that the right transfer RNA moves in where the mRNA directs it, so the protein being made will have the ...

These differences arise from structural elements in the human ribosome and in the human elongation factor, eEF1A, that together are responsible for faithfully incorporating the right tRNA for each ...

In mammals, this fidelity-determining reaction is facilitated by the GTPase elongation factor-1 alpha (eEF1A), which escorts aa-tRNA as an eEF1A(GTP)-aa-tRNA ternary complex into the ribosome. The ...

During elongation, elongation factor Tu (EF-Tu, eEF1A in eukaryotes) is used to deliver aminoacyl-tRNA (aa-tRNA) to the A-site of the ribosome, and elongation factor G (EF-G, EF2 in eukaryotes and ...

They landed on eEF1A, a protein that cells use to make other proteins, and its inhibitor plitidepsin, which is approved in Australia for treating multiple myeloma. SARS-CoV-2 hijacks eEF1A to make ...

In addition to the conserved translation elongation factors eEF1A and eEF2, fungi require a third essential elongation factor, eEF3. While eEF3 has been implicated in tRNA binding and release at the ...

Plitidepsin inhibits production of eEF1A, a protein that is used by cells to create other proteins. Prior research showed that the SARS-CoV-2 virus needs eEF1A to make its own proteins.

Aplidin inhibits the eEF1A protein, which is associated with the SARS-CoV-2 virus, and is approved in Australia as a multiple myeloma treatment. According to the recently published study, in vitro ...