inhibition of miR-200c alone or together with miR-141-3p protects from OGD-induced injury in microglial BV2 cells by reducing neuroinflammation and apoptosis. Overall, the Tgfβ2/Zeb1 pathway is ...

Through overexpression experiments, we show that miR-200s repress endogenous ZEB1 and ZEB2 expression in human myometrial cells. By overexpressing ZEB1 and ZEB2 in these cells, we establish that these ...

Fibroblast-specific Zeb1 knock-out in colorectal cancer models leads to a shift in myCAF and iCAF populations, promoting immune infiltration. This increases colitis-associated tumorigenesis, reduces ...

In this study, multi-omics analyses show that prostate cancer cells undergo an intermediate state marked by Zeb1 expression with epithelial-mesenchymal transition (EMT), stemness, and neuroendocrine ...

Regulons that are controlled by transcription factor ZEB1 are shared between the pathogenic subset in articular cartilage and meniscus. In meniscus and cartilage cells, FAP and ZEB1 promote expression ...

The biologists investigated the potential role of the protein ZEB1, known to increase cell plasticity, in breast cancer cell migration. ‘Unlike in women, mice transplanted with human breast cancer ...

On the basis of the above findings, in order to explore ZEB1-AS1/miR-590-5p underlying the molecular relationship in ox-LDL-treated endothelial cell damage, the effects of the ...

Further study suggested that ELK3 promoted PDAC cell migration and invasion by activating the Wnt/β-catenin pathway, and proved that ZEB1 could directly bind to the promoter of ELK3 to increase its ...

Circulation of tumor cells to destroy correlations in immune system of colorectal cancer patients. This is an ASCO Meeting Abstract from the 2021 ASCO Annual Meeting I. This abstract does not include ...

Zinc finger E-box binding homeobox 1 (ZEB1) is a prime element of a network of transcription factors controlling EMT and has been identified as an important molecule in the regulation of DNA damage, ...