Dong-A ST Co. Ltd. has disclosed transcriptional enhancer factor (TEAD) and/or transcriptional coactivator YAP1/TEAD interaction inhibitors reported to be useful for the treatment of cancer.

Three preclinical posters highlight potential use of NXP900 in NSCLC As a single agent, NXP900 potently inhibited YAP1 nuclear localization and the proliferation of YES1/YAP1-amplified NSCLC cells ...

Daewoong Pharmaceutical Co. Ltd. has described transcriptional coactivator YAP1/transcriptional enhancer factor (TEAD) interaction inhibitors reported to be useful for the treatment of cancer.

The title should instead appear as “Hapalindole Q suppresses autophagosome−lysosome fusion by promoting YAP1 degradation via chaperone-mediated autophagy.” The legends for Figs. 1, 5, and 6 appeared ...

We identify a modular mechanism of IGF-1-driven tumor promotion in the early steps of EwS pathogenesis, in which Yap1 plays a central role. Pharmacologic Yap1/Tead inhibition reverses the transformed ...

The team started with sarcoma data from The Cancer Genome Atlas. They found that two well-known oncogenes (YAP1 and KRAS) direct mesenchymal cells to become undifferentiated pleomorphic sarcoma ...

Here we show that human papillomavirus (HPV), which could reach FTECs via retrograde menstruation or sperm-carrying, interacts with the yes-associated protein 1 (YAP1) to drive the malignant ...

YAP1 activity regulated the ECM-CAF phenotype, and YAP1 silencing promoted switching to Lym-CAFs. NF-κB p65 was the core transcription factor in the Lym-CAF subset, and YAP1 inhibited nuclear ...

About half of all meningiomas are characterized by functional loss of a tumor suppressor called NF2, a core regulator of several cellular signaling pathways, including the transcription factor (and ...

aGenome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea bDepartment of Bioinformatics, KRIBB School of Bioscience, Korea ...

The Nrg1 loss- and gain-of-function transcriptomes were enriched for Yap1 (yes-associated protein-1) gene signatures, identifying Yap1 as a potential downstream effector. Furthermore, biochemical and ...