Mayo Clinic's Molecular Neurotherapeutics Lab demonstrated that maternal immune insults perturb microglial phenotypes and ...

Researchers found that the Wnt5a protein, secreted by inflammatory fibroblasts within cancerous tumors, inhibits angiogenesis and consequently promotes hypoxia within tumors. Hypoxic conditions help ...

The altered cells release factors that help tumors grow, such as epiregulin. In addition, they release Wnt5a protein, which helps maintain a low-oxygen state by inhibiting new blood-vessel ...

Methods and Results— We profiled gene expression in human macrophages exposed to lipopolysaccharide (LPS) and interferon (IFN)-γ in the presence or absence of recombinant activated protein C (APC) or ...

Further molecular analysis revealed that LRP1 interacts directly with Wnt5a, a key player in the non-canonical Wnt/planar cell polarity (PCP) pathway. By facilitating Wnt5a uptake and recycling ...

ROR1 is involved in the non-canonical Wnt signaling pathway mediated by Wnt5a, regulating the growth and invasion of tumor cells. It is closely associated with tumorigenesis and drug resistance, ...

Robinow syndrome is associated with gene mutations that impact WNT5A-initated cell signaling events. His team has found that WNT5A signaling primarily acts within cranial neural crest cells to ...

It has been previously demonstrated that the WNT gene/protein family member WNT5A is down-regulated in leukemia, and low expression of this tumor suppressor has been correlated with disease ...

A new editorial paper titled " Impact of cortactin in cancer progression on Wnt5a/ROR1 signaling pathway" has been published in Oncotarget. Cortactin (also known as EMS1 or CTTN) is expressed ...

We discovered that levels of a gene called Wnt5a are strongly correlated with the onset of those early skin changes – condensation and hyperplasia. Through a series of experiments involving cultured ...

We discovered that levels of a gene called Wnt5a are strongly correlated with the onset of those early skin changes – condensation and hyperplasia. Through a series of experiments involving ...

Myometrial cells act as a component of the niche and regulate the stem cell fate through the activation of WNT/β-catenin signaling via WNT5A. Since WNT5A-responsive mechanisms on eMSC are still ...