Guided by changes in steady-state expression levels of known FBW7 substrates in cystic tubules, we identified the SOX9-WNT4 axis as a crucial regulator of tubulointerstitial fibrosis and showed that ...

A network was formed from these genes, including Wnt/β-catenin signaling genes WNT4 and TCF7L2; dysregulation of these genes contributed to cancer immune evasion. "WTC exposure is associated with ...

ABSTRACT: Premature ovarian failure (POF) is a prevalent cause of female infertility. POF features include estrogen hypofunction, amenorrhea, infertility, and high gonadotropin levels. The etiology of ...

aNHC Key Laboratory of Viral Heart Diseases, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China ...

These results prompted us to investigate the cartilage of Prdm15 morphants. Alcian blue staining at the late tadpole stages indicated a spectrum of malformations of the cranial cartilages, in ...

Prince Henry’s Institute of Medical Research, 246 Clayton Road, Clayton, 3168, Australia * To whom correspondence should be addressed. Address: Prince Henry’s Institute of Medical Research, P.O. Box ...

Scientists now show that the gene Wnt4 in beta cells enables them to sense glucose and release the hormone insulin that enables other cells in the body to store glucose. These insights could help ...

The discovery of the role of Wnt4 in the development of a pancreas started in the 1990s at Harvard University, when Anne Grapin-Botton, a postdoctoral researcher at that time, discussed with Seppo ...

The pink blobs represent a muscle stem cell marker called Pax7 On closer inspection, the researchers found that the Yamanaka factors reduced levels of a protein called Wnt4 in the niche ...