Credit: Habib Lab, UNIL Intermittent fasting combined with localized Wnt3a treatments has been shown to rejuvenate bone repair in older mice, presenting a promising approach to reversing age-related ...

Here, we report that Wnt3a either induces O-GlcNAcylation rapidly via the Ca 2+-PKA-Gfat1 axis, or increases it in a Wnt-β-catenin-dependent manner following prolonged stimulation. Importantly, we ...

Using a high quality and active Wnt agonist is the most effective way for success of organoid culture. Wnt3a is considered a niche factor of organoid culture. There are two options as a source of ...

The membrane‐tethered protease Tiki antagonizes Wnt3a signaling by cleaving and inactivating Wnt3a in Wnt‐producing cells. Tiki also functions in Wnt‐receiving cells to antagonize Wnt signaling by an ...

These images showed that WNT3A, PORCN, and palmitoleoyl-CoA come together in a sandwich-type configuration, with PORCN in the middle flanked by the two other precursors. When WNT3A and PORCN were ...

2016). Furthermore, supplementation of Wnt3a can reduce the size of infarction areas after myocardial infarction (Tang et al., 2019). Other studies found the mechanism to reduce ischemia damage may be ...

Wnt signaling controls both development and homeostasis, and its disruption is implicated in a wide range of human diseases. 6-10 The human genome encodes 19 Wnt ligands, which have unique and yet ...

Recently, we discovered crosstalk between AMPA/Kainate-type ionotropic glutamate receptors (iGluRs) and the Wnt-pathway during the initial Wnt3a-interaction at the cytonemes of mouse embryonic stem ...

We used WNT3a to activate or LGK974 to block the pathway, and examined initiation of ciliogenesis, cilium length, and percentage of ciliated cells. We show that the treatment by WNT3a has no- or ...

In this study, we investigated a potential role of TRAF6 in Wnt-signaling in prostate cancer. Our study revealed a functional role for TRAF6 in Wnt3a signaling and prostate cancer progression through ...

Instead, we find that TFAP2 family members mediate the pro-lipid droplet signal induced by Wnt3a, leading to the notion that the TFAP2 transcription factor may function as a ‘master’ regulator of ...