Elephants seem to have 20 different copies of a tumor-suppressing gene known as p53. This gene encodes a protein, also known as p53, which serves as a crucial cell protector. This protein acts a ...

Sustained reactivation of mutant p53 drives durable anti-tumor activity across models, including KRAS co-mutant tumors FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

Here, we found mitotic spindle, WNT-beta catenin signaling, KRAS signaling, and lysosome gene sets to be positively enriched while oxidative phosphorylation, MYC targets, translation, and ribosome ...

CLSP-1025 is a half-life extended TCE targeting cancer cells expressing the p53 R175H mutant peptide presented by HLA-A*02:01. Data demonstrating the therapeutic potential of CLSP-1025 will be ...

A Wnt/β-catenin pathway agonist under development by Surrozen appears to be effective against idiopathic pulmonary fibrosis (IPF) in mouse models, according to new data. The results, published ...

[Keith Chambers/Science Photo Library/Getty Images] The p53 protein plays a significant role in cell biology as it regulates the cell cycle and halts the formation of tumors. Scientists have long ...

In a recent study published in the Cell Reports journal, researchers assessed the impact of protein adduction on p53 tumor suppressor inhibition. Studies have shown that exposing esophageal cells ...

Treatment approaches to address mutations or deletions of chromosome 17p are needed due to the surfacing of point mutations, including TP53 aberrations in chronic lymphocytic leukemia. With the ...

New cryo-EM images shed light on Wnt signaling Atomic-resolution pictures could eventually lead to better cancer drugs, researchers say Date: August 16, 2022 Source: UT Southwestern Medical Center ...

Constitutive activation of the tumor suppressor p53 in hepatocytes paradoxically promotes non-cell autonomous liver carcinogenesis.. Cancer Research , 2022; DOI: 10.1158/0008-5472.CAN-21-4390 Cite ...