Median baseline eGFR measured by Cockcroft-Gault was 89 mL/min/1.73 m² and 82 mL/min/1.73 m² with eGFR-CR-Cys. Average patient age was 66, 66% were female, and 83% were white.

Johnson & Johnson has produced the most convincing data to date that its combination of Rybrevant and Lazcluze could replace AstraZeneca’s Tagrisso as the new standard of care in first-line EGFR ...

EGFR was identified in DSRCT by Smith et al. due to the enrichment of EGFR-related pathways in a gene set variation analysis of DSRCT microarray data (Smith et al., 2022). While EGFR is highly ...

Pinetree Therapeutics will help AstraZeneca plant some trees in its pipeline with a new pact to develop a preclinical EGFR degrader worth $45 million upfront for the small biotech. AstraZeneca is ...

Background: Anti-EGFR therapies including cetuximab and panitumumab are recommended in frontline or later-line treatment regimens for left-sided metastatic colorectal cancer (mCRC) lacking mutations ...

Background: Immuno-STATs are modular fusion proteins designed for the selective activation of tumor antigen specific CD8+ T cells. CUE-102, the second Immuno-STAT in clinical trials, is composed of a ...

References: Mochizuki T, Matsukawa M, Tanaka T, Jiang H. Initial eGFR changes predict response to tolvaptan in ADPKD. Kidney360.Published online February 28, 2024. doi:10.34067/KID ...

Over a 20-year period, 1.12% of patients who were treated with EGFR inhibitors developed new-onset keratitis compared with 0.74% of those who did not take these drugs (HR 1.520, 95% CI 1.339-1.725 ...

(B) Increased avidity via an additional anti-WT1-HLA-A*02:01 Fab in WT1 TED2 split and tandem resulted in increased binding to WT1-HLA-A*02:01 compared to WT1 TED. EGFR TED was used as a negative ...

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

Telisotuzumab vedotin (ABBV-399) combined with erlotinib (Tarceva) showed promising antitumor activity and an acceptable safety profile in patients with epidermal growth factor receptor (EGFR)-mutated ...