Testing how Wt1 binding is affected by loss of Mafb provides insight into how these key podocyte TFs may cooperate to regulate genes. Weaknesses: The conclusion that Mafb is required for Wt1 binding ...

It is perhaps a little ironic that this long-sought factor is a variant of the Wt1 gene which was also described at the same time, however, with the complexity of the gene and the system, we ...

In the cardiovascular system, the Wt1 gene is highly expressed in the epicardium —the outer layer of the heart— and in the endothelial cells of this organ. "To date, it was thought that the defects in ...

New perspectives on Wt1 gene functions Endothelial cells form the inner cell layer of blood vessels and have a wide range of essential functions in the development of tissues and organs such as ...

In the cardiovascular system, the Wt1 gene is highly expressed in the epicardium —the outer layer of the heart— and in the endothelial cells of this organ. "To date, ...

The deletion of the Wt1 gene during the early stages of the embryonic reproductive organ formation leads to differences in sex development in adult mice, according to an article published in the ...

The Wt1 gene or Wilms tumour gene is expressed during the embryonic development of mammals in many organs and tissues (urogenital system, spleen, heart, diaphragm, etc.).

RELATED: Fighting leukemia by targeting a little-known protein The Fred Hutch scientists previously devised an engineered WT1 TCR T-cell candidate called TTCR-C4, which targeted the WT1 126-134 ...

The WT1 gene was cloned in 1990 (Gessler et al., 1990) and it was originally described as a classic tumor suppressor gene (Yang et al., 2007). However, WT1 is overexpressed in many hematological ...

The Wilms’ tumour 1 (WT1) gene was first investigated in 1990 due to its disease link with Wilms’ tumour (a paediatric kidney cancer). Thirty-years on, WT1 has taken us through a journey of many ...

Sex development involves a precise spatiotemporal expression and interactions of numerous genetic factors, including the WT1 (Wilms tumor 1) gene. Complete and partial loss-of-function WT1 variants ...

A new genetic engineering technology could help eliminate malaria and stave off extinctions — if humanity decides to unleash it. A Drosophila melanogaster fruit fly engineered with a gene drive ...