Cardiff Oncology's Onvansertib shows promise in treating RAS-mutated cancers, especially mCRC. See why I rate CRDF stock as a ...

Ordinarily, HIF-mediated induction of VEGF would provide a rapid and direct mechanism to protect motor neurons during such periods of mild hypoxia. But deletion of the HRE element in the VEGF gene ...

Hypoxia-inducible factors (HIFs), central regulators for cells to adapt to low cellular oxygen levels, are often overexpressed and activated in breast cancer. HIFs modulate the primary transcriptional ...

It has been shown that hypoxic conditions in the tumor microenvironment induce upregulation of HIF-1 and promote differentiation of ... and angiogenesis (e.g., VEGF and iNOS), respectively. Snail, a ...

US pharma giant Merck & Co today announced that the European Commission (EC) has conditionally approved two indications for Welireg (belzutifan), its oral hypoxia-inducible factor-2 alpha (HIF-2α) ...

"This is an important moment, and we are pleased that WELIREG, a first-in-class HIF-2α inhibitor, can now potentially help these patients in need." This approval allows marketing of WELIREG for ...

“This is an important moment, and we are pleased that WELIREG, a first-in-class HIF-2α inhibitor ... a PD-1 or PD-L1 inhibitor and at least two VEGF targeted therapies, is based on progression ...

Welireg is intended for adults with VHL disease who need therapy for associated renal cell carcinoma (RCC), central nervous ...

Edited by Anne C. Hart, Brown University, Providence, RI; received August 29, 2024; accepted December 19, 2024 by Editorial Board Member Yishi Jin Taken together, these results identify VHL-1 as a ...

BACKGROUND/AIMS Vascular endothelial growth factor (VEGF) plays a key role in regulation ... −789 suggesting a substantial contribution of the −975 putative hypoxia inducible factor 1 binding site to ...

Clinic Center of Human Gene Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. (C.W., W.X., S.J., Y.W., J ...