The Berger lab’s previous work identified USP9X, which is a deubiquitinase—an enzyme that removes ubiquitin marks from other proteins, as an important RIT1 regulator. “Ubiquitin chains can mark ...

For ankyrin-G to do its job properly, it needs to work together with an enzyme called Usp9X. This enzyme stabilizes ankyrin-G, ensuring that it can help the dendritic spines grow and develop normally.

However, ankyrin-G doesn’t work in isolation. It requires the help of an enzyme named Usp9X. This enzyme stabilizes ankyrin-G, ensuring that it can effectively contribute to the formation of ...

Contrary, it is reported that PD-L1 can be deubiquitinated by CSN5, USP22, USP7, USP9X, and OTUB1 (Feng et al.). PD-L1 expression fluctuates during the cell cycle; it increases in the M and early G1 ...

Mutations in a protein involved in autophagy The key is some very rare mutations in the USP9X protein, which regulates cellular processes critical for tumour growth. Roldán-Romero’s research ...

SEATTLE — April 6, 2023 — Experts from Fred Hutchinson Cancer Center will present their latest findings on targets in RIT1-driven cancers, ROR1 CAR T-cell immunotherapy, interplay of the microbiome ...

Rather, it serves to recruit an alternative set of DUBs, USP7, and USP9X, which directly deubiquitinate the AlkB proteins. Thus, OTUD4 serves primarily as a scaffold, bridging AlkB proteins to a multi ...

The E3 ligase activity residues were shown in red. The autoubiquitination of RNF115 is also counteracted by deubiquitinase USP9X. It has been recently reported that the deubiquitinase USP9X and RNF115 ...

Herein, we provide evidence that USP9x selectively drives Notch in breast cancer and that therapeutic USP9x inhibition prevents tumor progression without collateral damage to normal tissues.

Clancy et al. develop a specific chemical inhibitor of USP9X and characterize its effects upon the cellular proteome. This analysis reveals a central role in the regulation of ribosomal stalling ...