Plants have a sophisticated mechanism for monitoring the production of new proteins. The "U1 snRNP" complex ensures that the protein blueprints are fully completed. This is important because cells ...

Date: 17th April 2024. Time: 13:00. Title: Beyond Splicing: Unveiling Novel Roles of U1 snRNP in plants. Location: Lecture room B7, Forest Sciences Building, Latokartanonkaari 7-9. Host: Roosa ...

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The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research for ...

Alzheimer’s disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. Nature Aging , 2022; DOI: 10.1038/s43587-022-00290-0 Cite This Page : ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

The U1 snRNP complex is essential in RNA splicing. Now, Peng and his team have demonstrated that the dysfunction of the U1 snRNP contributes to neurodegeneration, opening new avenues of research ...

The RNA component of the snRNP is rich in uridine. The epitopes are the proteins complexed to the uridine-rich RNA. For example, what defines the U1-RNP antibody is its specificity to the 70-kDa ...

U1 Adaptors are bivalent oligonucleotides that engage sequence-specific mRNA and the U1 small nuclear ribonuclear protein (U1 snRNP), which is a ubiquitous intracellular machine that regulates ...

Ceptur’s use of synthetic oligonucleotides that engage U1 snRNP offers the ability to co-opt this master regulator of the transcriptome to regulate mRNA in a highly targeted fashion.

The company was founded, Ghoroghchian said, “to advance therapeutics based on U1 Adaptor technology. U1 Adaptors are small, synthetic RNA oligonucleotides that engage the U1 small nuclear ribonuclear ...