Background: Sunitinib is the main target drug for clear cell renal cell carcinoma. However, the effect of sunitinib is often limited by acquired drug resistance. Methods: The open-accessed data used ...

These experiments provide critical detail to our understanding of the cellular consequences of pathogenic LRRK2 mutation and indicate that LRRK2 blocks ciliogenesis upstream of TTBK2 and enhances the ...

Self-perception in patients is their self-response to sensory stimuli. It is an important aspect of the existence and quality of life among patients. However, the inherent relationship between ...

The cells were stained for acetylated tubulin (Ac‐tubulin, green) and TTBK2 (red). The graphs shown are the quantifications of TTBK2 intensity at cilia‐negative basal bodies and cilia‐positive basal ...

Decision letter after peer review: Thank you for submitting your article "TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons" for consideration by ...

The primary cilium needs the protein TTBK2 to assemble, and mutations in the gene that codes for this protein cause a neurodegenerative disorder that first appears in adulthood known as spinocerebral ...

Structural Genomics Consortium (SGC), UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill (UNC−CH), Chapel Hill, North Carolina 27599, United States Division of Chemical ...

Whenever we learn or save information, the so-called ionotropic glutamate receptors play a crucial role in the brain. These receptors are proteins that are located in the membrane of nerve cells ...