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ascopubs.org1mon
Safety and Activity of Fibroblast Growth Factor Receptor Inhibitors in Advanced Malignancies: A Pooled Analysis of Early-Phase Clinical Trials
Safety and Efficacy of Anti–Human Epidermal Growth Factor 2 Agents in the Treatment of Biliary Tract Cancers: A Systematic Review FGFRi are effective treatment strategies for patients with advanced ...
The Lancet1y
Whole exome sequencing and machine learning germline analysis of individuals presenting with extreme phenotypes of high and low risk of developing tobacco-associated lung ...
aDepartment of Pediatrics and Clinical Genetics, Clínica Universidad de Navarra (CUN), Cancer Center Clínica Universidad de Navarra (CCUN), Program in Solid Tumors, Center for Applied Medical Research ...
The Lancet1y
Rheumatoid arthritis
bNIHR Biomedical Research Centre, Leeds Teaching Hospitals Trust and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK Rheumatoid arthritis is a chronic, ...
Frontiers2y
Exploring the common diagnostic gene KCNJ15 and shared pathway of ankylosing spondylitis and ulcerative colitis through integrated bioinformatics
Introduction: The similarity between ankylosing spondylitis (AS) and ulcerative colitis (UC) in incidence rate and pathogenesis has been revealed. But the common pathogenesis that explains the ...
Frontiers2y
Cross Analysis of Genomic-Pathologic Features on Multiple Primary Hepatocellular Carcinoma
In contrast, case of Pt03 had low level of similarity between the two tumors. As shown by the phylogenetic tree, 345 mutations occurred in either of tumor, while only TNIP2 was a shared early mutation ...
eLife3y
Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model
Despite antigen affinity of B cells varying from cell to cell, functional analyses of antigen-reactive B cells on individual B cells are missing due to technical difficulties. Especially in the field ...
scienceopen.com3y
Neuroprotective Function of TNFAIP3 Interacting Protein 2 Against Oxygen and Glucose Deprivation/Reoxygenation-Induced Injury in Hippocampal Neuronal HT22 Cells Through ...
Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. TNIP2 expression was substantially declined in HT22 cells following OGD/R ...
eLife4y
Multiplexed proteomics of autophagy-deficient murine macrophages reveals enhanced antimicrobial immunity via the oxidative stress response
Effective immunity against enteric pathogens requires complex signaling to coordinate the inflammatory response, pathogen clearance, tissue remodeling, and repair (Maloy and Powrie, 2011). Autophagy, ...
scienceopen.com4y
miR-423 Promotes Breast Cancer Invasion by Activating NF-κB Signaling
TNIP2, an important inhibitor of the NF-κB pathway, is known to involve a negative feedback loop of the NF-κB signaling cascade and to regulate tumor aggressiveness in various cancer types. However, ...
ahajournals.org6y
Human Monocyte Heterogeneity as Revealed by High-Dimensional Mass Cytometry
From the Division of Inflammation Biology, La Jolla Institute for Allergy and Immunology, La Jolla, CA (A.A.J.H., H.Q.D., G.D.T., P.M., A.B., C.S.N., C.C.H.) From the ...
ascopubs.org7y
Enrichment of FGFR3-TACC3 Fusions in Patients With Bladder Cancer Who Are Young, Asian, or Have Never Smoked
Impact of Variable RNA-Sequencing Depth on Gene Expression Signatures and Target Compound Robustness: Case Study Examining Brain Tumor (Glioma) Disease Progression We correlated somatic FGFR3-TACC3 ...