This study provides evidence that single-cell multi-omics profiling can reveal key regulators of HIV-1 persistence and early immune dysregulation, particularly implicating KLF2 and Th17 cells as major ...

Aclaris Therapeutics (ACRS) announced the availability of a new publication describing properties of Aclaris Therapeutics’ ATI-2138, a novel ...

IL-17A, IL-17F and bimekizumab monoclonal antibodies were used to block IL-17 cytokine action. Results Recombinant IL-17A and IL-17F are pro-osteogenic with respect to hPDC differentiation. T helper ...

Studies in animal models suggested that Th17 cells are the candidates ... Our comprehensive analysis of cytokine production demonstrates the landscape of helper T cell populations in RA joints: ...

While displaying T cell suppressive activity, MDSCs from arthritic mice produced high levels of inflammatory cytokines (eg, interleukin (IL)-1β, TNF-α). Mouse and human MDSCs promoted Th17 cell ...

as well as skin tissue infiltration and Th2/Th17 immune bias in SSc[4]. However, there is limited research on CD4+T cell subsets in MCTD, and the characteristics of these subsets are not well ...

One of the most recent and perhaps most promising developments in psoriasis research is the role of the Th17 CD4 + T cell and one of its cytokines, IL-17, in disease development, progression and ...

Transcriptomic analysis revealed that cDCs from B27-rats under express IL-27, an anti-inflammatory cytokine which induces the differentiation of IL-10 + regulatory T cells and inhibits Th 17 cells.

The IL-20 receptor (R) cytokines IL-19, IL-20, and IL-24 are produced in both ... by myofibroblasts and IL-26 stimulation of monocytes is an important inducer of Th17 cells in RA. This indicates a ...