MDNA11 significantly expands a unique population of ‘stem-like’ CD8+ T cells that leads to more persistent and effective anti-tumor activity MDNA11 has shown durable single agent activity, with a 30% ...

As a consequence, the temperature coefficients of frequency of the 1st order (TCF1) have opposite signs at room temperature, leading to the vanishing TCF1 of the double resonators. Frequently, ...

These cells are marked by two specific proteins, PD1 and TCF1, which help determine their behaviour, including self-renewal and regulation. In lab models, activating these cells made a common ...

These cells are marked by two specific proteins, PD1 and TCF1, which help determine their behavior, including self-renewal and regulation. In lab models, activating these cells made a common ...

The researchers show that T cell exposure to interleukin-15 -- an immune factor important for Tcm formation -- and their expression of a protein named TCF1 engages the PPARβ/δ pathway.

The adoptive transfer UC mouse model demonstrated that helper T lymphocytes deficient in TCF1 or BCL-6, transcription factors promoting T lymphocyte stemness, had fewer colon T lymphocytes and ...

Specifically, we tracked the activity of a gene called T cell factor 1, or TCF1. This gene is essential for the longevity of memory cells. We found that stochastic, or probabilistic, silencing of ...

Their findings were published in Immunity in a paper titled, “Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision.” Insights from studies like ...

The Xue lab in the two successive Nature Immunology publications has focused on a key dynamic of T-cell immunology: the Tcf1 transcription factor and its far-reaching molecular complexity.

The Xue lab in the two successive Nature Immunology publications has focused on a key dynamic of T-cell immunology: the Tcf1 transcription factor and its far-reaching molecular complexity.