Mutations in TBX1 and other 22q11.2 genes may cause learning differences, intellectual disabilities, psychiatric disease, seizures, muscular hypotonia, or stunted growth.

Several variants identified in the research involved the genes TBX1, CRKL, HIC2, and MAPK1, which are required for vascular development, especially the left ventricular outflow tract, which passes ...

In their study, published in Nature Communications in December 2024, Zakharenko and his team discovered that mice lacking part of a gene called Tbx1 on chromosome 22 had abnormalities due to the ...

And these malformations can be traced back to a gene called Tbx1. Related: AI pinpoints where psychosis originates in the brain "What is interesting about Tbx1 is that it is not very well ...

St. Jude researchers linked cerebellum malformations in 22q11.2 deletion syndrome to abnormal skull development and the loss of the Tbx1 gene, shedding light on new neurological pathways involved in ...

A recent study has revealed that brain volume changes, particularly in the amygdala and its subregions, correlate with social behavior variations in psychiatric disorders like autism and schizophrenia ...

Led by Zakharenko's colleague Tae-Yeon Eom, the researchers found that in mouse models deletion of one copy of the Tbx1 gene disrupts skull bone formation during development, leading to a malformed ...

Researchers created mice without the the Tbx1 gene, which Hiroi and colleagues had previously identified as a critical regulator of stem cell function in the brain, according to a UT Health news ...

Among these, the Tbx1 gene has emerged as a critical regulator of stem cell function in the brain, as highlighted in prior studies by Hiroi and colleagues. Variants in Tbx1 are strongly associated ...

Further, the researchers linked the skull malformation to the loss of one gene: Tbx1. The research shows that neurological disorders can stem from sources beyond the nervous system, such as ...

Summary: A new study reveals how genetic deficits, particularly in the Tbx1 gene, are linked to reduced brain volume and altered social behavior, findings relevant to autism and schizophrenia.

Among these, the Tbx1 gene has emerged as a critical regulator of stem cell function in the brain, as highlighted in prior studies by Hiroi and colleagues. Variants in Tbx1 are strongly associated ...