Results: Our findings revealed that knocking out ADAR1 induces dsRNA accumulation, activating the TBK1-IRF3 pathway and stimulating ISG expression, which in turn activates anti-tumour immunity and ...

Emma Raducanu is set to face Iga Swiatek in the second round of the French Open on Wednesday. The British ace faces a tough test against world No. 5 Siwatek, and the pair have history with each other.

BETTENDORF, Iowa — During a city council meeting on Tuesday night, Bettendorf approved plans for a new pedestrian bridge near the TBK Bank Sports Complex. A public hearing took place before the ...

SOLO, KOMPAS.com – Presiden ke-7 Joko Widodo kembali bicara soal gagasannya untuk menciptakan partai super terbuka di Tanah Air.. Jokowi menyebut gagasannya itu telah diakomodasi oleh Partai ...

IRF3 is a key transcription factor required for the antiviral innate immune response. After receiving the upstream TBK1 signal, IRF3 activates type I IFN signaling through multiple processes, ...

Indosat Tbk PT. Follow. 20 results. March 12, 2025. I Squared, Macquarie vie for stake in Indosat's $1 bln fibre business, sources say.

Its key role in IRF3 activation involves phosphorylating innate adapter proteins MAVS, STING1, and TICAM1 on their pLxIS motif, recruiting IRF3 and licensing it for phosphorylation by TBK1.

ASFV 17, an ER-Golgi localized membrane protein, can effect on IRF3 activation via several mechanisms. It can interact with STING and recruit PR65A, a subunit of cellular phosphatase PP2A, to ...

Statin therapy may prevent cancer by blocking inflammatory protein Study results indicate that pitavastatin inhibits interleukin-33 to suppress skin and pancreatic cancers ...

Liquid-liquid phase separation (LLPS) driven by protein multivalent domains or intrinsically disordered regions (IDRs) emerges as a general mechanism for the assembly of biomolecular condensates.

Here, we found that interferon regulatory factor 3 (IRF3), but not TANK-binding kinase 1 (TBK-1) or IκB kinase epsilon (IKKε), was recruited and sequestered in viral IBs when the cells were infected ...