Metabolic dysfunction-associated steatohepatitis (MASH) significantly increases the risk of liver cirrhosis and hepatocellular carcinoma. While fibroblast growth factor 21 (FGF21) analogs have shown ...

The clinical criteria are divided into major (M) and minor feature (m): Definite TSC: 2 major features OR 1 major and 2 or more minor Possible: Either 1 major or 2 or more minor features The presence ...

It occurs due to a variation in either the TSC1 or TSC2 gene. Neurofibromatosis refers to three different conditions. These conditions are neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and ...

Among patients with TSC2 mutations, 2 achieved a CR, 6 had a PR, and 1 had SD. Among patients with TSC1 mutations, there were no CRs, 1 PR, and 3 cases of SD. The median progression-free survival ...

Analysis of inactivating TSC1 and TSC2 alterations in advanced genitourinary (GU) cancers from a real-world patient population in the Foundation Medicine genomic database. AMBASSADOR Alliance A031501: ...

Phase 2, multicenter, open-label basket trial of nab-sirolimus for patients with malignant solid tumors harboring pathogenic inactivating alterations in TSC1 or TSC2 genes (PRECISION I).

Here, we use whole‐genome CRISPR‐Cas9 knockout data to uncover an important role for Tuberous Sclerosis Complex 2 (TSC2) in determining tumor susceptibility to cytotoxic T lymphocyte (CTL) killing in ...

Angiomyolipoma is a type of noncancerous kidney tumor consisting of fat, muscle, and blood vessels. It can cause pain and other complications. In some cases, a doctor may remove it ...

KO PCCs subjected to amino acid starvation failed to modulate mTOR signaling to reduce protein synthesis and transcriptomic data show upregulated TSC2 and downregulated SERBP1 genes. Therefore, our ...