Activated AKT phosphorylates TSC1/2 and relieves its inhibition function on mTORC1, promoting protein translation. AKT also phosphorylates and inhibits GSK3β, initiating glucose metabolism and ...

and TSC1/2, tuberous sclerosis protein 1/2. In recent years, the mTOR complexes have emerged as crucial regulators of cardiovascular embryonic development, homeostasis, and adaptation to stress. In ...

Aadi Bioscience’s Fyarro is on track to fail a phase 2 solid tumor trial ... mTOR inhibitor-naïve malignant solid tumors harboring TSC1 or TSC2 inactivating alterations. But Aadi revealed ...

Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest 2020; 130: 2111-2128. 32. Goodwin JM, Dowdle WE, DeJesus R, et al.

It occurs due to a variation in either the TSC1 or TSC2 gene. Neurofibromatosis refers to three different conditions. These conditions are neurofibromatosis 1 (NF1), neurofibromatosis 2 (NF2), and ...

PRECISION 1: A phase 2, multicenter, open-label basket trial of nab-sirolimus for malignant solid tumors harboring pathogenic inactivating alterations in TSC1 and TSC2. This is an ASCO Meeting ...

The Apple Watch Ultra 2 is a modest update over the original, but a brighter display, support for the double-tap gestures and future-proof processor are welcome improvements. While we still crave ...

By utilizing dopamine neuron-specific Raptor and Rictor cKO mice, this paper elucidated which of these mTOR complexes are responsible for the regulation of dopamine neuronal functions, revealing the ...

First rigorous analysis estimates TSC1 and TSC2 definite impact alteration incidence in U.S. as approximately 12,000 advanced cancer patients in 2030 Findings also identify highest frequency of TSC1 ...

a Phase 2 registrational trial of nab-sirolimus in patients 12 years and older with solid tumors with pathogenic inactivating alterations in TSC1 and TSC2 genes. The FDA granted Aadi Fast Track ...

discuss the lack of clinical benefit of sapanisertib for the treatment of TSC1/TSC2mutated mUC. Forty-one patients were screened for inclusion In the phase 2 study of sapanisertib, and of those ...

Clinically, the level of TRIM6, TSC1/2, and NF-κB p50 was found closely related to renal fibrosis. As a result, we have presented the first study on the role of TRIM6 in the mTORC1 pathway in renal ...