The financing round was jointly led by new investor Regeneron Ventures and current investor Deerfield Management.

The funds will support the firm's lead programs, ABS-1230 for KCNT1-related epilepsy and ABS-0871 for TRPV4-positive Charcot-Marie-Tooth disease type 2C.

TRPV4-ir was not detected on the membrane of the cells in the TG neuron pellet. In addition, only low levels of Trpv4 mRNA in mouse TG sections were identified in 4.0% ± 0.6% of neurons by RNAscope ...

TRPV4 is an ion channel that regulates the concentration of calcium inside cells, which is important for many cellular processes. Mutations in the TRPV4 gene cause an increase in channel ...

Endothelial cell TRPV4 (transient receptor potential vanilloid 4) channels provide a control point that is pivotal in regulating blood vessel diameter by mediating the Ca 2+-dependent release of ...

Their next step was to examine whether TRPV4 also played a role in human perspiration. Their research included a study of the skin of patients with Acquired Idiopathic Generalized Anhidrosis or ...

Representative TRPV4 staining in sweat glands from normohidrotic and anhidrotic skin from the same patient with acquired idiopathic generalized anhidrosis (AIGA). Sweating is a vital process in a ...

Mice lacking TRPV4 had reduced sweating and were less able to climb a slippery slope, suggesting that a layer of sweat helps improve traction. Finally, Kashio et al. compared samples obtained from ...

One study published in the journal Drugs in Context (Oct. 11, 2023) identified the transient receptor potential channel TRPV4 as contributing to acute cough associated with rhinovirus infection.

Lead Program Targeting TRPV4 Advancing Toward the Clinic. Actio’s pipeline is led by a program targeting TRPV4, an ion channel target identified as high-value through the company’s platform.

Analysis of different types of TRPV4 mutant hiPS cells (mild V620I vs severe T89I mutations) showed alterations in calcium channel function and chondrocyte differentiation. hiPSC-derived chondrocytes ...