Delving into why summer exacerbates this heaviness, Dr Aslam said: "When temperatures climb, blood vessels naturally dilate. While this helps regulate body temperature, it also makes it harder for ...

Hydrate and move : Drinking plenty of water and exercising regularly are key to keeping your circulation healthy - and your ...

Stretch: If you’ve been on your feet all day, simple stretches can make a big difference. Try hamstring and calf stretches, ankle rolls, and toe flexes to help relieve tension, improve circulation and ...

The active ingredient in Tryptyr is acoltremon, an agonist of transient receptor potential melastatin 8 thermoreceptors.

The U.S. Food and Drug Administration has approved the first-in-class TRPM8 receptor agonist Tryptyr (acoltremon ophthalmic solution) for the treatment of signs and symptoms of dry eye disease.

Engineering of TRPM8 channel to be activated by CHXOL and more sensitive to CHXOL.  FAYETTEVILLE, GA, UNITED STATES, May 30, 2025 /EINPresswire.com/ -- In a breakthrough advancement for neuroscience, ...

The FDA has approved Tryptyr (acoltremon) as the first TRPM8-targeting eye drop for dry eye disease, stimulating natural tear production as early as day one.

The FDA approved Tryptyr to treat the signs and symptoms of dry eye disease, according to a press release from Alcon. Tryptyr (acoltremon ophthalmic solution 0.003%), formerly known as AR-15512 ...

In pivotal Phase 3 trials, TRYPTYR demonstrated rapid natural tear production as early as Day 1 1-2 TRYPTYR is a first-in-class TRPM8 receptor agonist that rapidly stimulates natural tear ...

Activated TRPM8 receptors can suppress the release of CGRP, a neuropeptide that depletes dopamine in the brain, and increase levels of interleukin-10, an anti-inflammatory protein in the body that ...

MANCHESTER, England & MOUNTAIN VIEW, Calif., August 27, 2024--Axalbion, a clinical-stage biopharmaceutical company focused on developing novel medicines to treat cough, announced that the first ...

TRPM8 is also involved in many other types of pain as well, including chronic neuropathic and inflammatory pain. By further understanding this specificity of the chemical sensing of cold versus ...