A 3D engineered kidney glomerulus model replicates structural and mechanical features of the glomerular filtration barrier, ...

serving as mechanical and topographical cues that ultimately drive cell… TRPC6 Inhibition for Scleroderma Treatment Scleroderma is a rare disease characterized by chronic tissue hardening (fibrosis), ...

The seminar programme will take place online until further notice. External interested parties are requested to register in advance with the secretariat of the Institute by e-mail (see below), where ...

Enzyme-linked immunosorbent assay (ELISA), western blot, quantitative polymerase chain reaction and immunofluorescence staining were utilized to evaluate glutathione peroxidase 4 (GPX4) and transient ...

Most strikingly, this approach eventually identified a specific mechanosensitive ion channel named TRPC6 as a key biosensor essential for neuronal responses to ultrasound neuromodulation in the intact ...

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This study evaluated the efficacy and safety of the transient receptor potential channel C6 (TRPC6) inhibitor, BI 764198, in reducing the risk and/or severity of ARDS in patients hospitalised for ...

Northwest Agriculture & Forestry University has disclosed short transient receptor potential channel 6 (TRPC6) antagonists reported to be useful for the treatment of cancer, sepsis, arthritis, ...

Blocking a calcium channel called TRPC6 prolonged survival in a mouse model of Duchenne muscular dystrophy (DMD) by improving skeletal and heart muscle function and reducing bone deformities, a study ...

Researchers at the Johns Hopkins University School of Medicine (MD, USA), led by senior author David Kass, have demonstrated that pharmacologically blocking the ion channel transient receptor ...

The new study, published Sept. 13 in the Journal of Clinical Investigation - Insight, reports that a drug blocking the ion channel called TRPC6 in mice with severe DMD doubled their survival and ...

The observed variability is not restricted only to loop E1 and E2 of TRPC6: also the loop pre-S1 and S1 of TRPC5 shows a similarly complex unfolding behavior as opposed to the unfolding of the loop ...