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Belo Sun Mining (TSX: BSX) soared on Thursday after the Brazil-focused gold developer won a federal court ruling that is deemed positive for the permitting process of its flagship Volta Grande ...
Closed: Development of small molecules targeting the TRF1 subunit of the telomeric Shelterin complex
To answer this question, we have embarked on a programme to develop a chemical probe to directly modulate the incorporation of TRF1 into Shelterin (Casale et al., manuscript in preparation). We ...
We postulate that repression of telomeric replication stress is a shared mechanism of control of telomerase recruitment and telomere length, common to several core telomere binding proteins including ...
Brazil’s “reconstruction” project for the BR-319 (Manaus-Porto Velho) highway and associated side roads would open vast areas of Amazon forest to the entry of deforesters and loggers, writes ...
However, with a profound responsibility to serve approximately 86 million people, TRF1 faced the urgent task of finding a solution to ensure the continued operation of the judicial system. Driven by ...
Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. However, whether long telomere length is advantageous is poorly ...
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States Department of Biochemistry & Biophysics, School of Medicine, ...
The Ukrainian military began to use French TRF1 155mm howitzers. The first footage of these howitzers in Ukraine was shown by Andriy Tsapliyenko, a Ukrainian journalist. According to him, howitzers ...
Ukraine has received six TRF1 155mm towed howitzers from France. It is reported by Ouest-France with reference to French Defense Minister Sébastien Lecornu. It is noted that overall France has handed ...
French government sends Ukraine TRF1 towed 155 mm howitzers, which Nexter Systems (French government-owned weapons manufacturer) has started producing in 1984. Despite the “age”, this weapons have ...
Human shelterin is a six-subunit complex—composed of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—that binds telomeres, protects them from the DNA-damage response, and regulates the maintenance of telomeric ...
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