BOCA RATON, FL / ACCESSWIRE / November 25, 2024 / Empyrean Therapeutics, Inc., a pioneering biopharmaceutical company, today announced the successful acquisition of a first-in-class novel TLR-2 ...

Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. February 14, 2024 Microbial colonization is a well-documented cause of a small ...

Response: Previous studies have found that VP35, rather than NP, inhibits the expression of interferon, and the “VP35+NP” treatment, which induces IRF3 sequestration, showed inhibited IFN-β luciferase ...

Glucocorticoids dramatically inhibit cytokine and chemokine production. They act through the glucocorticoid receptor (GR), a ligand‐dependent transcription factor that binds to and represses ...

Activation of downstream signaling molecules NF-κB and IRF3 in TLR signaling requires polyubiquitination of intermediate signaling molecules such as MyD88, TRIF, TRAF6, TAB2/3, NF-κB essential ...

TLR/IL-1R family possesses an intracellular conserved Toll/IL-1R (TIR) domain which can allow the recruitment of the adapter MyD88 for the transduction of signals . ... TRIF is recruited to promote ...

The data is lack of demonstration of the effect of Vpr on the natural/endogenous KPNA1-IRF3/NF-κB signalosome. Authors should provide sufficient and convincing evidence (ISGs, p-IRF3 and p-p65 ...

IRF3 and IRF7 activation depend on PI3K and mTORC1 in pDCs, and a blockade of these pathways results in decreased type I IFN responses to TLR stimulation (19–22). Conversely, FOXO1 and FOXO3, ...

We show that antibacterial TLR activation causes a selective suppression of STING-mediated type I IFN gene expression by targeting the IRF3 transcription factor without affecting TANK-binding kinase-1 ...

The TRAF3-TBK1-IKKε-IRF3 complex is central to both TLR-dependent and TLR-independent production of IFN-α/β and antiviral responses 19,20,36,37,38,39.

The competition model predicts that in a reverse scenario, microbial TLR–IRF3 activators will limit the amount of GRIP1 available to GR, thereby inhibiting its transcriptional regulatory properties.