ANKL is a rare and aggressive type of blood cancer affecting a type of white blood cell called natural killer (NK) cells. In ANKL, the NK cells are abnormal and multiply out of control ...

We studied the association of TI-CH with survival and disease recurrence and evaluated the functional effect of TET2-mutant CHIP on the biologic features of lung tumors. Among patients with NSCLC ...

TET2 mutations were the strongest genetic predictor of tumor-infiltrating clonal hematopoiesis. In this study, age-associated tumor-infiltrating clonal hematopoiesis emerged as an important factor ...

In a study (34), 33 MDS/chronic myelomonocytic leukemia (CMML) patients carrying TET2/IDH mutations and 23 healthy controls were analyzed by flow cytometry for NK cell surface markers, including ...

“RMAT designation for ANKTIVA combined with NK cells was applied for by the Founder in the initial 2017 IND. With the clinical results of the QUILT trials across multiple tumor types from 2017 ...

Approximately 30% of individuals with myeloid malignancy diseases have a mutation in a certain gene called tet methylcytosine dioxygenase 2 (TET2). This gene is responsible for providing ...

Scientists have now discovered why a mutation in a gene called TET2 is often implicated in disorders including diabetes, heart disease, stroke, inflammatory diseases, and certain types of cancer. This ...

The other members of the TET family act on DNA, so for years, researchers had been looking at TET2’s effects on DNA. But He’s lab found they’d been looking in the wrong place: TET2 actually affects ...

The CAR-NK program, dubbed CB-020, was an induced pluripotent stem cell (iPSC)-derived allogeneic anti-ROR 1 cell therapy aimed at solid tumors. Caribou already revealed in March that it had ...

In two racially diverse cohorts with a total of 8090 adults, TET2 CHIP was independently associated with > twofold higher risk of incident HFpEF. By contrast, there were no significant ...