Genetically engineered New York esophageal squamous cell carcinoma 1 (NY-ESO-1)–targeted, TCR/IL-15–expressing cord blood–derived NK cells are being investigated in a phase 1/1b trial of patients with ...

After having talked about it here, we return once again to the renewed TCR Advanced platform by Giant to give you our impressions on it. We were able to test the tenth iteration of the most iconic of ...

Samsung has not one, but two new smartwatches for this year. Though it's true the Galaxy Watch 6 and Galaxy Watch 6 Classic have more in common than not, there are a couple of key differences you ...

IL-6 was found to regulate PD-L1 mutually, and its elevation correlated with disease failure and poor prognosis for HNSCC (11–13). We shall review the oncogenic IL-6/JAK/STAT3, EGFR/RAS/MEK/ERK, ...

In particular, TILs cultured in IL-21 + conditions demonstrated the highest number of cluster-related TCRs, which is indicative of a more prominent influence of antigen-driven TCR selection. We ...

(2021-10-05) TCR² Therapeutics Presents Preclinical Data on IL-15 Enhanced TRuCs at AACR Virtual Special Conference on Tumor Immunology & Immunotherapy Stockhouse.com uses cookies on this site. By ...

In addition, IL-15 promoted the survival of TRuC-T cells in the absence of T cell receptor (TCR) or exogenous cytokine stimulation. In a mesothelioma xenograft mouse model, IL-15 co-expression ...

TCR2 Therapeutics Inc. (Nasdaq: TCRR), a clinical-stage cell therapy company with a pipeline of novel T cell therapies for patients suffering from cancer, today announced the e-poster presentation of ...

Graphical Abstract Background and Purpose: T lymphocytes contribute to secondary brain damage after stroke. It has not been fully investigated whether this contribution is caused by antigen-specific ...

Importantly, MAIT cell IL-17A and IL-17F production induced by E. coli, with or without IL-12 and IL-18 stimulation, was IL-23 independent. A low level of TCR independent IL-17A and IL-17F production ...

Mechanistically, we found that IL-6 inhibited up-regulation of IL-2Rβ (CD122) by preventing association of STAT5 with the Il2rb locus, thus allowing GC-TFH cells to receive sustained TCR ...