Tumor development is an evolutionary process driven by an accumulation of mutations allowing cells to acquire traits that can ultimately lead to a cancerous state. [1] As a consequence cancer is ...

Center for Reproduction and Genetics, Department of Obstetrics and Gynecology, First Affiliated Hospital of USTC, Hefei National Research Center for Physical Sciences at the Microscale, the CAS Key ...

Novel Treatment Targets in Sarcoma: More Than Just the GIST MYC has proven to be a highly potent oncoprotein when it is overexpressed, but is also a pleiotropic transcription factor essential for ...

CDD-2807 stands out for its ability to inhibit a protein known as serine/threonine kinase 33 (STK33), which is widespread in the testes of mammals. Studies have shown that sperm cells from humans and ...

The protein, a kinase called STK33, has been linked to infertility in male mice and humans. Researchers from Baylor College of Medicine, in collaboration with scientists at Promega Corporation ...

The new method involves inhibiting the protein serine/threonine kinase 33 (STK33), which men require for fertility. The team identified a molecule that inhibits STK33 temporarily in mice ...

Men and male mice who have mutations in a protein called STK33 are sterile. The researchers synthesized several different compounds, which would bind with STK33 and inhibit it. Of the several they ...

Researchers have identified an inhibitor targeting the kinase STK33, crucial for male fertility, that effectively induces reversible infertility in male mice without adverse effects. This breakthrough ...

In the research, scientists used a small molecule to inhibit serine/threonine kinase 33 (STK33) – a protein known to be specifically required for fertility in both mice and men. Previous ...