The biconcave disk shape and deformability of mammalian red blood cells (RBCs) rely upon the membrane skeleton, a viscoelastic network of short actin filaments interconnected by long spectrin ...

Panel A shows the structure of dystrophin, including its four hinge domains and 24 spectrin-like domains, flanked by the N-terminal domain in red, the cysteine-rich domain in yellow, and the C ...

“We have demonstrated that βII-spectrin, previously thought to be an intracellular protein, is in fact exposed on the surface of mesangial cells and directly recognized by the IgA ...

It is caused by a mutation in the β-III-spectrin gene, which is critical for creating connections between neurons in the central nervous system. Adam Avery, the assistant professor at Oakland ...

Communicated by Vincent T. Marchesi, Yale University School of Medicine, New Haven, CT, February 11, 2010 (received for review November 8, 2009) Three identified human pedigrees link mutations in βIII ...

Studies have shown that βII spectrin is necessary for cardiomyocyte survival and differentiation, and its loss leads to heart development defects and cardiomyocyte apoptosis. Additionally, previous ...

Find more information on the Altmetric Attention Score and how the score is calculated. Spectrin is a cytoskeletal protein ubiquitous in metazoan cells that acts as a liaison between the plasma ...

Abstract: The spectrin-based membrane skeleton is a major component of the cell cortex. While expressed by all metazoans, its dynamic interactions with the other cortex components, including the ...

This study shows that βH‐spectrin is a key regulator of apical ratcheting during tissue invagination, suggesting that actin crosslinking plays a critical role in this process. The actin crosslinker βH ...

We then explore the contributions from the various cytoskeletal components of the axon to show that the recently discovered membrane-associated actin-spectrin scaffold plays a prominent mechanical ...

Alpha-spectrin provides both strength and flexibility to red blood cell membranes, helping cells maintain their shape and integrity while making their circuit through the body, he explained. Cells ...