Panel A summarizes the conventional model of how oncogenic RAS guanosine triphosphatases (i.e., Kirsten rat sarcoma viral oncogene homologue [KRAS], neuroblastoma RAS viral oncogene homologue ...

The FDA has approved sotorasib with panitumumab for adult patients with KRAS G12C-mutated metastatic colorectal cancer (mCRC) whose disease progressed after chemotherapy. The FDA has approved ...

The FDA has approved the combination of sotorasib (Lumakras) and panitumumab (Vectibix) for the treatment of patients with previously treated KRAS G12C-mutated metastatic colorectal cancer (CRC). The ...

The following is a message from the Director of the FDA Oncology Center of Excellence, Dr. Richard Pazdur: On January 16, 2025, the Food and Drug Administration approved sotorasib (Lumakras, Amgen Inc ...

Immune proteins (purple) hold KRAS-sotorasib (yellow hexagons) at the surface of a tumor cell (orange). An antibody (green) carrying radioactivity (yellow halo) detects KRAS-sotorasib and grabs onto ...