aDepartment of Pulmonary and Critical Care Medicine, China-Japan Friendship Hospital, Capital Medical University, Beijing, 100054, China bNational Center for Respiratory Medicine, State Key Laboratory ...

Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor erythroid 2-related factor 3) has an established role in ...

In this study, the authors use the zebrafish to investigate how the microbiome affects a specialized gut cell called the lysosome rich enterocyte. They use a combination of functional assays for ...

Microbes slow the rate of soluble cargo uptake in LREs. (A) Cartoon depicting experimental design of the gavage assay in GF and CV larvae. Following derivation under conventional (CV) or germ-free (GF ...

Ileal Sodium/Bile Acid Co-transporter is encoded by SLC10A2 gene. It plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine and cholesterol ...

Elobixibat is an inhibitor of IBAT, which is an alternative name for the apical sodium bile acid transporter (ASBT) encoded by the SLC10A2 gene. ASBT/IBAT is a bile acid:sodium symporter responsible ...

Find more information on the Altmetric Attention Score and how the score is calculated. The apical sodium-dependent bile acid transporter (ASBT, SLC10A2) facilitates the enterohepatic circulation of ...

We previously reported that ASBT/SLC10A2 mRNA was downregulated by apple-derived extracellular vesicles (APEVs). ASBT downregulation is effective in the treatment of cholestasis and chronic ...

Moreover, overexpressed slc10a2 in NSCLC cells can more significantly limit the proliferating and migrating processes, and promote apoptosis under the treating process of bexarotene. As opposed to ...

cDepartment of Infectious Diseases and Center for Liver Diseases, Peking University First Hospital, Beijing, China Primary biliary cholangitis is an autoimmune liver disease that predominantly affects ...