The histone deacetylase Sir2 provides a seductive link between gene silencing and calorie restriction (CR), 1 but many debate the mechanism. Now researchers are turning to a new question: Does Sir2 ...

The RENT complex is known to compact rDNA. To see if the RENT complex could be responsible for rDNA silencing during quiescence, they investigated Sir2, one of the main members of the RENT complex.

The company’s pipeline products include SIR2446 and SIR9900, SIR2, SIR3, SIR4, SIR5, SIR7(biologics) and SIR6(biologics) that treats age-related degenerative diseases. Sironax pipeline programs focus ...

This paper presents a mechanistic study of rDNA origin regulation in yeast by SIR2. Each of the ~180 tandemly repeated rDNA gene copies contains a potential replication origin. Early-efficient ...

It works by creating a negative feedback loop between two genes — SIR2 and HAP4 — controlling nucleolus or mitochondrial aging, reining in the two modes from ever getting ahead of each other ...

The complex examined in this study, the combination of proteins called SIR2 and HerA, was identified along with hundreds of other bacterial defense systems in previous research that focused on ...

SIRT6 is a member of the Sir2-like protein family. Mammalian sirtuins can be divided into four classes according to their core domain sequences. SIRT6 and SIRT7 are class IV sirtuins (29). SIRT6 has ...

But how does this switching ability occur? “When we got rid of the Sir2 gene, we saw less of the true hyphae form,” says Zhao, first author and a PhD candidate in biological sciences, College of Arts ...

A protein called Sir2 may facilitate C. albicans' transition from ovoid yeast to thread-like hypha. C. albicans cells that were missing the Sir2 gene were less likely to form true hyphae in lab ...

But how does this switching ability occur? "When we got rid of the Sir2 gene, we saw less of the true hyphae form," says Zhao, first author and a PhD candidate in biological sciences in the UB ...