We propose that the intermediary RBM17–SAP30BP complex prevents non-functional RBM17 binding to free unphosphorylated SF3B, which promotes functional RBM17 binding to active phosphorylated SF3B1 ...

We propose that the intermediary RBM17­­­–SAP30BP complex prevents non-functional RBM17 binding to free unphosphorylated SF3B, which promotes functional RBM17 binding to active phosphorylated ...

Nat. Comm., 2021). SF3B ligands with antitumor properties act as competitive antagonists of branch sites (see SF3B-PB, SF3B-SSA, SF3B-SUD). Our structures explain why the inhibition depends on the ...

Nat. Comm., 2021). General mechanism of splicing modulation by SF3B ligands SF3B ligands with antitumor properties act as competitive antagonists of branch sites (see SF3B-PB, SF3B-SSA, SF3B-SUD). Our ...

By using a series of photoaffinity-labeling derivatives of GEX1A, we found that GEX1A targeted SAP155 protein, a subunit of SF3b responsible for pre-mRNA splicing. The linker length between the GEX1A ...

Intraoperative MRI-Guided Resection Is Not Superior to 5-Aminolevulinic Acid Guidance in Newly Diagnosed Glioblastoma: A Prospective Controlled Multicenter Clinical Trial This clinical trial's ...

Figure 4 Alternative splicing as downstream targets for SRPK, CLK, and Sf3b and resistance to CLK or SF3b inhibitors. Only the alternatively spliced isoforms and the flanking exons are shown (not at ...

Treatments targeting splicing factor mutations have mainly included developing pan-splicing modulators, including bacterially derived products and analogs that have been shown to bind the SF3B ...

Purpose: Ovarian and uterine clear cell carcinomas (CCCs) are rare but associated with poor prognosis. This study explored RNA transcription patterns characteristic of these tumors. Experimental ...

A Systematic Review and Meta-Analysis on the Predictive Value of Cell-Free DNA–Based Androgen Receptor Copy Number Gain in Patients With Castration-Resistant Prostate Cancer Age and exposure to ...

(DOI: 10.1021/acschembio.9b00833) take a look at the mRNAs that are altered when cancer cells in a dish are treated with FD-895, a natural product targeting the spliceosomal SF3B protein. Using RNA ...