A defining molecular feature is the presence of STAT3 mutations, with STAT5B mutations occasionally observed in CD4+ variants. Clonality is confirmed by T-cell receptor (TCR) gene rearrangement.

STAT5B also prevents further differentiation of hematopoietic cells together with the corepressor complex of deacetylase. This corepressor complex cannot be released by ATRA and this may explain the ...

We provide an integrated analysis of chromatin accessibility and transcriptional profiles in paired human SAT and OVAT samples, offering new insights into the regulatory landscape of adipose tissue ...

Nevertheless, in both cell types, only STAT5B was phosphorylated. The impact of STAT5B activity at the maternal-fetal interface is unknown, however observations have linked aberrant activation of ...

STAT5B is a known downstream signaling target of BCR::ABL1. 20 The identified STAT5B mutation corresponds to the DNA-binding domain, which has not been described in Ph+AML. For IKZF2, the identified ...

Reduced Stat5b expression is responsible for adult neurogenesis defects in Derlin-1-deficient NSCs. Inhibition of histone deacetylase activity effectively induces Stat5b expression and restores ...

Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.

Furthermore, Stat5b-KD-induced apoptosis in GSCs was significantly inhibited by Myb overexpression. Down-regulation of Myb mediates Stat5b-KD-induced inhibition of proliferation and induction of ...

Inborn errors of immunity (IEIs) are immunological disorders characterized by variable susceptibility to infections, immune dysregulation and/or malignancies, as a consequence of damaging germline ...