Compared with tezepelumab, solrikitug demonstrated unique epitope binding and superior potency across several assays.

Delve into the STAT6 degrader technology and what it could bring to inflammatory and allergic disease treatment.

The technique could be developed into a novel oncology treatment vectorA team at the University of Michigan (U-M) has developed a novel approach to cancer immunotherapy by reprogramming a herpes ...

As expected, the protein increased levels of STAT (specifically the protein STAT5) in T cells in a Petri dish. They then tested the protein on mice with melanoma and lymphoma.

An engineered viral protein activates STAT5 to prevent T cell suppression. Science Immunology , 2025; 10 (107) DOI: 10.1126/sciimmunol.adn9633 Cite This Page : ...

STAT5 activator mechanism. Credit: Science Immunology (2025). DOI: 10.1126/sciimmunol.adn9633 Recent research points to the potential utility of a familiar sounding foe–herpes virus–in ...

In a study published in Nature, University of Michigan researchers have identified that the balance between two proteins – STAT3 and STAT5 – is important for making tumors vulnerable to immune ...

Phosphorylation of endogenous STAT5 in the human leukemia cell line UT-7/EPO, which expresses the EPO receptor (EPO-R) and is EPO-dependent, was stimulated by the different doses of purified EPO ...

ATI-2138 dose-dependently decreased JAK1/JAK3-dependent IL-2-stimulated STAT5 phosphorylation in human peripheral blood mononuclear cells (PBMCs) with low-nanomolar potency while having no ...

Jens H Nielsen, University of Copenhagen, Department of Biomedical Research, Panum Institute, Bldg 6.5, Blegdamsvej 3C, DK-2200 Copenhagen N, Denmark Disclosure: The authors have no other relevant ...

STAT5 activity is negatively regulated by different phosphatases, the class of PIAS and SOCS proteins. In β-cells, SOCS3 in particular attenuates growth hormone- and prolactin-induced STAT5 ...