The STAT1 signaling pathway has been shown to be involved in the regulation of SCA-1 expression (Yang et al., 2017), suggesting a role for STAT1 in the modulation of SCA-1 during development of TI.

Summary: Researchers have uncovered a link between the immune gene regulator STAT1 and hyperactive behaviors in mice, offering new insights into neurodevelopmental disorders like autism and ADHD.STAT1 ...

We identified that prolonged dysfunctional EGFR signaling in the hair follicle leads to scarring hair follicle destruction. Transcriptional profiling of the hair follicle stem cells during alopecia ...

Conclusions. We present this case to increase CMC awareness and as a reminder that it is an immune disease, not only a dermatologic one. It may refer to the STAT1 GOF gene pathological variant, or it ...

The patient was found to have a heterozygous c.821G→A p.(Arg274Gln) pathogenic variant in the gene encoding signal transducer and activator of transcription 1 (STAT1), as previously reported ...

Background Heterozygous STAT1 gain-of-function (GOF) mutations result in a predisposition to early-onset humoral autoimmunity, including lupus-like disease. Since multiple STAT1-dependent cytokines ...

Background Human genetic variations resulting in immunodeficiency and/or the propensity for autoimmunity represent “experiments of nature” that can advance our understanding of polygenic human ...

Usually, the scariest part of childhood vaccination, for both kids and parents, is the needles. In rare cases, however, vaccines can have unexpectedly negative effects, and the secret lies in our ...

The article, “Novel STAT1 variants in Japanese patients with isolated Mendelian susceptibility to mycobacterial diseases,” was published in the Journal of Clinical Immunology at DOI: 10.1007 ...