In a complementary study, published in Biochemical Journal, the team identified three key proteins—MYO1B, MYO5B, and SNX27—that are essential for positioning and stabilizing MUC17 on the ...

In a complementary study, published in Biochemical Journal, the team identified three key proteins—MYO1B, MYO5B, and SNX27—that are essential for positioning and stabilizing MUC17 on the surface of ...

[1 ]Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China [2 ]Department of Pathogen Biology, School of Clinical and Basic Medical Sciences, Shandong ...

At the neuronal synapse, SNX27 recycles PDZ-binding receptors and its defective expression is associated with synaptic dysfunction and cognitive impairment. In T lymphocytes, SNX27 was found localized ...

The sorting nexin proteins are critical for endosomal trafficking and signaling. SNX17 and SNX27 are two SNX proteins displaying high similarity in domain structure, including a common FERM domain; ...

The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To ...

Phosphorylation of Ser-1459 promotes GluN2A interaction with the sorting nexin 27 (SNX27)-retromer complex, thereby enhancing the endosomal recycling of NMDARs. “Loss of SNX27 or CaMKIIa ...

The team found that two SLiMs in ACE2 bound to the endocytosis-related proteins SNX27 and SHANK, and one SLiM in the integrin β3 bound to two proteins involved in autophagy. In addition to providing a ...

Sorting nexin 27 (SNX27) is a metazoan-specific sorting nexin protein from the PX-FERM domain family and is required for endosomal recycling of many important transmembrane receptors. Multiple studies ...

The team found that two SLiMs in ACE2 bound to the endocytosis-related proteins SNX27 and SHANK, and one SLiM in the integrin Beta-3 bound to two proteins involved in autophagy. In addition to ...