Despite initial suggestion of an association between the reduced effect of methylphenidate (MPH) and the SLC6A3 ( DAT1) 10-repeat polymorphism, this association has been challenged by subsequent ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Dopaminergic neuron dysfunction has been ...

Polymorphisms in the gene SLC6A3 for the dopamine transporter (DAT) have been associated with DAT availability in the human brain. This finding suggests an effect of these polymorphisms, or of ...

Table 1. Studies assessing the role of the dopamine transporter gene ( SLC6A3/DAT1) in clinical response to methylphenidate among individuals with attention deficit hyperactivity disorder.

MM-402 is under clinical development by Mind Medicine MindMed and currently in Phase I for Autism Spectrum Disorder (ASD). According to GlobalData, Phase I drugs for Autism Spectrum Disorder (ASD) ...

fUniversité Paris Cité et Université Sorbonne Paris Nord, Inserm, INRAE, Centre de Recherche en Épidémiologie et Statistiques, Paris, France gUniversity of Rennes, Inserm, Ecole des Hautes Etudes en ...

spatialAUC is a powerful Python package designed to calculate spatial autocorrelation of gene sets using Moran's I statistic. It offers a streamlined and efficient way to analyze the spatial patterns ...

This current revision builds on observations in validated conditional double KO (cDKO) mice for LRRK1 and LRRK2 that will be useful for the field, given that LRRK2 is widely expressed in the brain and ...

IL-6 and SLC6A3 as key targets. The binding activity of key targets with paeoniflorin was later verified by molecular docking. This study demonstrates for the first time that paeoniflorin regulates ...

The mTOR pathway is an essential regulator of cell growth and metabolism. Midbrain dopamine neurons are particularly sensitive to mTOR signaling status as activation or inhibition of mTOR alters their ...