The validated tumor antigen SLC45A2 was found to be overexpressed in the patient’s metastatic tumor based on RNA expression profiling. Peripheral blood derived SLC45A2-specific HLA-A2402-restricted ...

Their findings highlight three specific regions, SLC24A5, SLC45A2 and OCA2 in the genes of African Americans that show strong associations with skin color and vitamin D deficiency. The scientists hope ...

One such prediction, SLC45A2, has emerged as a particularly promising target due to its high tumor specificity and immunogenicity. In addition to T-cell neoantigens, the team has discovered a ...

Native American ancestry had the highest effect on pigmentation and reduced it by more than 20 melanin units, while the European mutations in the genes SLC24A5 and SLC45A2 and an African gene variant ...

Some of them have been widely reported, such as MC1R, HERC2, OCA2, TYR, TYRP1, SLC45A2, and three new candidates (C1QTNF3, C1QTNF3-AMACR, and LINC02876) with regulatory potential were unveiled ...

The graceful black swan is a familiar sight in waterways across Australia, but it could disappear if avian flu ever takes hold here. That's the grim conclusion of an international study that ...

A 2013 paper published in the Journal of Current Biology identified the gene as SLC45A2, a genetic variant known to also cause lightened pigmentation in horses, fish and chickens. In the wild, this ...

To date, several genes conferring high risk such as CDKN2A, CDK4, TERT, POT1, ACD TERF2IP; and genes conferring moderate risk such as MC1R, MITF and those associated with oculocutaneous albinism (TYR, ...

“Surprisingly white considering the gene variant SLC45A2 didn’t elevate to a noticeable degree until 5800 years ago - brings into question the reconstruction builders bias." And they were not ...

A facial reconstruction of a 5,500-year-old man found near Stonehenge has sparked debate online after it came out 'surprisingly white'. The model was made after remains of a neolithic man ...