and OCTN2 (SLC22A5 −207G→C) variants within the IBD5 locus have been associated with susceptibility to adult onset Crohn’s disease (CD), but their contribution in children has not been examined.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The human solute carrier (SLC) superfamily of ...

Chemistry Research Laboratory, Department of Chemistry and the Ineos Oxford Institute for Antimicrobial Research, University of Oxford, 12 Mansfield Road, Oxford OX1 3TA, U.K. Chemistry Research ...

Plasma acylcarnitine profile and the genetic study confirmed CPT II deficiency. Additionally, likely pathogenic variants in the SLC22A5 gene point to primary carnitine deficiency. Antenatal findings ...

Nat Clin Pract Gastroenterol Hepatol. 2006;3(7):390-407. Adhesion molecules such as intercellular cell adhesion molecule 1 (ICAM1) are necessary for circulating cells to be able to stick to the ...

Background: The relationship between appendectomy and Crohn’s disease is controversial. A Swedish–Danish cohort study was conducted to assess the risk of developing Crohn’s disease after an ...

Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool L69 3GL, U.K. *Mailing Address: Dr. David Dickens, Department of Molecular and Clinical Pharmacology, Wolfson ...

Intracranial aneurysms (IAs) remain a challenging neurological diagnosis associated with significant morbidity and mortality. There is a plethora of microsurgical and endovascular techniques for the ...

Human Genome Project Chromosome 5 is the 12th chromosome to have completed gene sequencing in the Human Genome Project. It comprises 9 million base pairs that make up 923 genes. Sixty-six of the ...

Newborns with low free carnitine (C0) levels were recalled. Mutation in the SLC22A5 gene was analyzed on suspected positive newborns with low C0 levels after recall. Results: 1,247,274 newborns were ...