Scientific evidence suggests that by downregulating Grb2 expression, BP1001-A could help lower blood glucose levels by affecting insulin signaling. Bio-Path conducted preclinical studies that ...

Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals ... (NSH3, SH2, CSH3), where the two SH3 domains (NSH3, CSH3 ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have uncovered new insights into how the proteins GRB2 and SOS1 in cells pass signals from membrane receptors to nuclei. They used ...

Recently, a zebrafish protein SH3-domain GRB2-like 3 (Sh3gl3) was identified as a potential regulator of blood vessel lumen maintenance. 5 Morpholino knockdown of Sh3gl3 caused a significant reduction ...

The SH3 domains of GRB2 bind proline-containing sequences on intracellular ligands that drive further downstream signaling. GRB2-mediated complexes regulate cell cycle progression, motility, ...

This important study reports an unexpected mode of activation of the critical immune cell kinase, Btk, by the SH3-SH2 domain-containing adaptor protein Grb2. The authors convincingly demonstrate that ...

The authors have previously established that the binding of the NCK and GRB2 SH2/SH3 adaptor proteins to their cognate pTyr sites in the C-terminal cytoplasmic domain of the viral A36 protein embedded ...

Grb2 is an adaptor protein that recruits Ras-specific guanine nucleotide exchange factor, Son of Sevenless 1 (SOS1), to the plasma membrane. SOS1 exchanges GDP by GTP, activating Ras. Grb2 consists of ...

Since the two SH3 domains of Grb2 bind competitively to both Sos1 and Dab2, to their proline-rich motifs, expression levels and phosphorylation of Dab2 and Sos1 modulate the abundance of Sos1/Grb2 ...

2 proteins compete for 1 port on a growth factor; 1 promotes metastasis, the other blocks it Rivals' relative expression levels in cancer cells could be biomarkers for prognosis, treatment ...